Pancreatic cancer. The evidence for a relationship between tomato or tomato-based food consumption and reduced risk of colorectal cancer is based on two case-control studies from the United States and Italy. Some evidence suggests that having higher lycopene blood levels is associated with a lower risk of breast cancer. Your email address will not be published. In young men, taking the recommended dose of lycopene increased sperm mobility and healthy shaped sperm by 40%. Lycopene is LIKELY SAFE when taken by mouth in appropriate amounts. Regular consumption of lycopene-rich foods has been reported to be associated with a 30 to 40% lower risk of prostate cancer (3,4), and lycopene rather than other carotenoids is inversely correlated to risk of prostate cancer (3,5–7). Neither case-control study found a relationship between tomato or pizza consumption and colorectal cancer risk reduction. High blood pressure during pregnancy. Serum and tissue lycopene levels have been inversely related to the risk of prostate and lung cancers. Lung cancer. Lycopene is a naturally present, lipid soluble carotenoid (with non-provitamin A activity) in tomatoes which gives fruits and vegetables red color.Lycopene is often regarded as an effective remedy for the prevention of certain malignancies, especially prostate cancer. 2004Q-0201) https://www.fda.gov/food/ingredientspackaginglabeling/labelingnutrition/ucm072767.htm, Claudine J. Kavanaugh, Paula R. Trumbo, Kathleen C. Ellwood; The U.S. Food and Drug Administration’s Evidence-Based Review for Qualified Health Claims: Tomatoes, Lycopene, and Cancer, JNCI: Journal of the National Cancer Institute, Volume 99, Issue 14, 18 July 2007, Pages 1074â1085, https://doi.org/10.1093/jnci/djm037. Early research shows that taking lycopene by mouth daily for 3 months improves sperm quality in some men with fertility problems due to unknown causes. Lycopene is found in tomatoes, watermelons, pink grapefruits, pink guavas papaya, and rosehip. Early research shows that taking lycopene by mouth, alone or together with other ingredients, might protect against sunburn. One study suggests that higher lycopene blood levels are associated with a lower risk of developing cataracts. A 2000 study in India examined thirty men with idiopathic infertility. Based on these studies, FDA concludes that it is unlikely that tomatoes reduce the risk of gastric cancer.”, The qualified health claim for ovarian cancer was âOne study suggests that consumption of tomato sauce two times per week may reduce the risk of ovarian cancer; while this same study shows that consumption of tomatoes or tomato juice had no effect on ovarian cancer risk. Early research shows that taking a specific lycopene supplement by mouth (LycoRed, Jagsonpal Pharmaceuticals) for 2 weeks or receiving a single injection of lycopene gel into the gums reduces gingivitis. Qualified Health Claims: Letter Regarding Tomatoes and Prostate Cancer (Lycopene Health Claim Coalition) (Docket No. In a 2002 study, patients with diagnosed prostate cancer showed a decrease in plasma prostate specific antigen after 3 weeks of lycopene supplementation in the amount of 15 mg twice/day. Sunburn. Diabetes Though studies are conflicting, lycopene has been associated with the prevention of diabetes. A healthy immune system is the body's best defense against illness. Kopec R, Schwartz SJ, Hadley C: Lycopene. Kidney cancer (renal cell carcinoma). Based on the above, FDA concludes that there is no credible evidence supporting a relationship between tomato or tomato-based food consumption and breast cancer. Studies have found that Lycopene can protect your DNA, your prostate health, your skin and your bones. Also, increasing dietary lycopene does not seem to prevent heart attacks in men at low risk for heart disease. Uses of Lycopene. Infertility Research has associated lycopene with an increased sperm count in men with low fertility rates. However, this study found that combining olive oil, but not sunflower oil, with tomatoes resulted in greater plasma antioxidant activity. Early research shows that taking lycopene by mouth daily for 2 months improves ulcerations in the mouth in people with oral mucositis. Thereâs no evidence of lycopene toxicity from diet. Harvard Medical School. Their semen was analyzed after the three-month period and twenty patients showed an improvement in sperm concentration, sixteen had improved motility and fourteen showed improvement in sperm morphology. Therefore, FDA concludes that there is no credible evidence to support a relationship between the consumption of tomatoes or tomato-based foods and cervical cancer risk. Lyc-O-Mato®, containing 15 milligrams of lycopene, has been taken by mouth daily for six weeks and eight weeks. Lycopene also protects your eyes from oxidative stress that causes common eye diseases, making it one of the stronger eye vitamins you can consume. Some research suggests that increasing lycopene consumption in the diet, or higher lycopene blood levels, is linked with a lower risk of developing prostate cancer. This pigment is a effective antioxidant that can help protect against degenerative diseases. FASEB J. Lycopene is the most common carotenoid in the human body and is one of the most potent carotenoid antioxidants and scavenger of free radicals and have also been shown to be a hypolipaemic agent, inhibitor of pro-inflammatory and pro-thrombotic factors 4), 5). Users should consult with a qualified healthcare provider for specific questions regarding therapies. Lycopene. However, other research shows that the risk of developing ovarian cancer is not linked to lycopene blood levels. Results from several in vitro and animal studies have indicated that lycopene may have chemopreventive effects for cancers of the prostate, skin, breast, lung, and liver; however, human trials have been inconsistent in their findings. There is evidence that dietary fat may help increase the absorption of carotenoids, including lycopene. Your heart and lungs are the center of your cardiovascular system, and lycopene is their friend. As an antioxidant, lycopene has been taken by mouth in doses of 6.5, 15, and 30 milligrams daily for eight weeks. Sera samples collected before and after the interventions were incubated with lymph node cancer prostate cells to measure the expression of 45 target genes. https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djm037, United States Department of Agriculture Food Composition Databases. Lycopene shows antioxidant and anticancer properties. 1. The oxidative damage caused by free radicals has been linked to many degenerative diseases such as cardiovascular diseases, cancer and cataracts. https://www.ncbi.nlm.nih.gov/pubmed/8529833. Lycopene is an antioxidant that provides a variety of supporting functions in humans. http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD008007.pub2/abstract, Kavanaugh CJ, Trumbo PR, Ellwood KC: The U.S. Food and Drug Administration’s evidence-based review for qualified health claims: tomatoes, lycopene, and cancer. Colorectal cancer. Antioxidants protect the body from free radicals, which can result in oxidative stress. These foods deliver all the lycopene befits that exist. Furthermore, you may be getting the wrong form of lycopene in a supplement. However, other research suggests that there is no link between lycopene consumption in the diet or lycopene blood levels and lung cancer risk. Ulcers and swelling in the mouth (oral mucositis). Lycopene is a phytochemical that belongs to a group of pigments known as carotenoids. Lists of natural carotenoids. 79 no. The researchers suggested that lycopene, in addition to its ability to attack free radicals, may also reduce inflammation and cholesterol, improve immune function, and prevent blood from clotting. They made this connection after following more than a thousand middle-aged men for 12 years. Some evidence suggests that higher lycopene blood levels or higher lycopene intake in the diet is linked to a lower risk of cervical cancer. Early research shows no link between lycopene consumption in the diet and the risk of developing kidney cancer. Lycopene for skin safeguards the dermal cells against the harmful UV rays from the sun. The FDA found no credible evidence to support an association between lycopene intake and a reduced risk of prostate, lung, colorectal, gastric, breast, ovarian, endometrial, or pancreatic cancer 31). When the subjects consumed 8-16mg of the supplement for 12 weeks, the group suffered less severe skin reactions. 1995;9:1547â1550. : 2. 240 mL (one cup) of tomato juice provides about 23 mg of lycopene. The lycopene in supplements is about as easy for the body to use as lycopene found in food. Early research shows that taking a specific combination of lycopene, selenium, and saw palmetto by mouth for 8 weeks reduces pain in men with prostate swelling and pelvic pain compared to saw palmetto alone. There are also a lot of compounds in food that arenât lycopene but that are similar, and some of those molecules may be part of what makes lycopene so beneficial 37). Also found in cell membranes and plays an effective role in maintaining the cell’s integrity when it is under assault by toxins. Lycopene Health Benefits for Men. Here is a short list: You are probably wondering what foods contain lycopene. https://medlineplus.gov/druginfo/natural/554.html, NCI Thesaurus. Though it can be found as a … http://www.mayoclinic.org/drugs-supplements/lycopene/dosing/hrb-20059666. To prevent or treat prostate cancer, two milligrams of lycopene has been taken by mouth twice daily, and four milligrams of lycopene has been taken by mouth twice daily for one year. Lycopene shows antioxidant and anticancer properties. Some research shows that women with higher levels of lycopene in their blood have a lower risk of developing heart disease. Daily supplements containing up to 120 mg of lycopene have been used safely for up to one year. Lycopene inhibits androgen receptor expression in prostate cancer cells in vitro and along with some of its metabolites, reduces prostate cancer cell proliferation and may modulate cell-cycle progression 23). One cup (240 mL) of tomato juice provides about 23 mg of lycopene 7). Lycopene benefits the skin by helping it resist ultraviolet rays. A study conducted at the All “India Institute of Medical Sciences” found that lycopene, can boost sperm concentrations in infertile men. Benign Prostatic Hyperplasia, caused by non-cancerous growth of the prostate, creates a flurry of side effects, including frequency, urgency, straining and Nocturia.And men with frequency issues can experience the problem often because of prostate growth and weakening P.C. Processed tomato products have high amounts of lycopene than raw tomatoes. Lycopene (molecular formula: C40H56) is a linear, unsaturated hydrocarbon carotenoid, the major bright red pigment, a phytochemical found in fruits such as tomatoes and other red fruits such as papaya, pink grapefruit, apricots, red oranges, watermelon, rosehips and guavas 3). LycoRed® softules, providing a total daily dose of 10 milligrams of lycopene, have been taken daily for three months. Olson JA, Krinsky NI. Lycopene has been taken by mouth in the form of tomato products, capsules, and Lyc-O-Mato® in doses of 39.2-80 milligrams for 1-12 weeks 40). Were given 2000 micrograms of lycopene, twice a day for 3 months. However, measures of lycopene intake have been based on eating tomatoes, not on the use of lycopene supplements. Cervical cancer. Antioxid Redox Signal 10 (3): 475-510, 2008. https://www.ncbi.nlm.nih.gov/pubmed/18154485?dopt=Abstract, Ilic D, Forbes KM, Hassed C: Lycopene for the prevention of prostate cancer. However, other research shows no link between lycopene intake and the risk of heart attack or stroke in women. However, other research suggests that lycopene does not affect blood pressure during pregnancy. In one experiment, healthy volunteers consumed mixed-vegetable salads with nonfat, low-fat, or full-fat salad dressing. Healthy males participated in a crossover design study that attempted to differentiate the effects of a tomato matrix from those of lycopene by using lycopene-rich red tomatoes, lycopene-free yellow tomatoes, and purified lycopene. As a natural pigment made by plants, lycopene helps to protect plants from light-induced stress 18) and it also transfers light energy during photosynthesis 19). Lycopene is a powerful antioxidant with many health benefits, including sun protection, improved heart health and a lower risk of certain types of cancer. Lyc-O-Mato® capsules (each containing up to 15 milligrams) have been taken by mouth once daily for eight weeks and 26 days, or twice daily for four months. None of these 3 studies supported a relationship between tomato or tomato-based food intake and lung cancer risk reduction. However, other research suggests that there is no link between lycopene levels or lycopene intake and the risk of age-related eye disease. Women with higher levels of lycopene in their blood seem to recover from cancer-associated HPV infection faster than women with lower lycopene blood levels. Research about how lycopene affects the risk of colorectal cancer is inconsistent. Thirty healthy men aged 50 to 70 years were randomly assigned to two groups with each group consuming 200 g/d of yellow tomato paste (lycopene, 0 mg) and 200 g/d of red tomato paste (lycopene, 16 mg) as part of their regular diet for 1 week, separated by a 2-week washout period. Tomato is one of the best natural sources where you can find lycopene. U.S. National Library of Medicine. Lycopene reduces the risk of skin redness by half. Lycopene is readily absorbed by the organism and is naturally present in human plasma and tissues in more concentrations than the other carotenoids. More evidence is needed to rate lycopene for these uses. Free radicals are molecules that have at least one unpaired electron. Two LycoRed® softules (each containing 2,000 micrograms of lycopene) have been taken by mouth daily for six months 47). In this placebo-controlled trial, circulating lycopene concentration increased only after consumption of red tomato paste and purified lycopene. Indeed, the term lycopene is derived from tomato’s scientific name, Solanum lycopersicum. Lycopene also protects your skin, thanks to its photoprotective properties. doi: 10.1002/14651858.CD008007.pub2. FDA concluded that there was very limited credible evidence for qualified health claims for tomatoes and/or tomato sauce and a reduced risk for prostate, gastric, ovarian, and pancreatic cancers provided that the qualified health claims were appropriately worded so as to not mislead consumers” 29). Ulcers caused by H. pylori infection. Protects the Heart: Lycopene rich foods prevent the oxidation of LDL (bad cholesterol) from clogging the arteries. Neither of the studies found a relationship between tomato or tomato-based food intake and breast cancer risk. However, other research shows no link between lycopene intake or blood levels and prostate cancer risk. How the added that larger studies are needed to confirm the findings and to figure out if the stroke protection is due to lycopene or healthy lifestyle habits, because a high lycopene consumer is likely to eat more vegetables and not be a smoker 28). In 2004, FDA received two petitions for qualified health claims regarding tomatoes and/or lycopene and cancer risk reduction from The Lycopene Health Claim Coalition (consisting of H. J. Heinz Company, LycoRed Natural Products Industries, Ltd, The Morningstar Company, and The Prostate Cancer Foundation) and American Longevity, Inc. In experimentation with cataract development by the Department of Pharmacology at the All India Institute of Medical Sciences, it was discovered that lycopene may have the ability to prevent or … To treat infertility, 2,000 micrograms of lycopene has been taken by mouth twice daily for three months 46). https://www.fda.gov/food/ingredientspackaginglabeling/labelingnutrition/ucm072760.htm, U.S. Food and Drug Administration. An Italian study showed that people who ate at least one tomato-based product per day had a 50 percent lower chance of contracting digestive tract cancer than those who did not eat tomatoes. Diabetes. Research suggests that there is no link between lycopene consumption in the diet or lycopene blood levels and the risk for bladder cancer. However, there does not appear to be a link between lycopene levels and stroke risk. Lycopene may also affect the insulin-like growth factor (IGF) intracellular pathway in prostate cancer cells. To treat enlarged prostate, 15 milligrams of lycopene (LycoVit®) has been taken by mouth daily for six months 41). Recently, lycopene has gained popularity among nutritionists and scientists due to its benefits on patients suffering from heart disease, cancer and diabetes. Lycopene is an antioxidant that is present in red- and pink-colored fruits and vegetables. Early research shows that taking a specific lycopene product (LycoMato, LycoRed Corp., Organge, NJ) daily for 8 weeks lowers blood pressure in people with high blood pressure. Lycopene (Ï,Ï-carotene), one of more than 600 carotenoids synthesized by plants and photosynthetic microorganisms 15), is a tetraterpene hydrocarbon containing 40 carbon atoms and 56 hydrogen atoms with a molecular mass of 536 16). https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=NCI_Thesaurus&code=C2226, Van Breemen RB, Pajkovic N. Multitargeted therapy of cancer by lycopene. Research on the effects of lycopene in people with asthma is inconsistent. Lycopene antioxidant effect is twice as high as that of beta carotene and ten times higher than that of alpha tocopherol. One of the biggest benefits of lycopene is that it is an antioxidant and protects the body of damage from free radical stress, which can hurt DNA and other cell structures. Two LycoRed® softules (each containing 2,000 micrograms of lycopene) have been taken by mouth daily for six months. Other studies have not found this link. Symptoms of menopause. The important carotenoids in the human body include; beta-carotene, alpha-carotene, lutein, cryptoxanthin, zeaxanthin and lycopene. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using. Early research shows that taking lycopene by mouth for 3 months does not improve the response to radiotherapy and chemotherapy in people with brain tumors. Lycopene. Free oxygen radicals are one of the important causes of male infertility, and antioxidant lycopene is known to get rid of these free radicals. By donating an electron lycopene can stabilize the free molecule. However, other research shows that neither lycopene intake nor lycopene blood levels are linked to breast cancer risk. men's health in middle age is mainly about prostate health problems. Breast cancer. They combat inflammation, thereby preventing serious ailments like cancer and heart disease. In response to these petitions, FDA evaluated evidence for associations between lycopene (a food component) and tomatoes (a food) separately and each form of cancer. Prostate cancer. However, in other research, taking lycopene daily for up to one year did not seem to help treat prostate cancer. Research about how lycopene affects the risk of lung cancer is inconsistent. Evidence is strongest for lycopene protective effect against cancer of the lung, prostate, and stomach. 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